Dedicated bongo drummer Richard Feynman won a Nobel Prize in physics.
Ansel Adams pursued a career as a concert pianist until he turned 30, when he switched his focus to photography.
Henry VIII, who moonlighted as king of England, was reportedly an exceptional musician on lute, keyboards, flute, harp, and recorder, sang and composed, and dabbled in a dozen other instruments. His children, Mary and Edward (VI) are said to have been remarkable lutenists, trained by Philip Van Wilder.
Let's see, there was also the prolific liturgical composer Ivan the Terrible (not his pen name).
Frederick II of Prussia wrote over 100 flute sonatas and four symphonies, but the demands of leading Europe's superpower during the Seven Year's War ended his music career.