Both happened to me. After almost 30 years on a 667 mm guitar with a 54 mm neck the successor, a 52/650 Kohno, felt like a big relief until a 52/664 Yairi came and proved that comfort is not related to numbers.
Now a new acquisition came with 53/660 which initially felt a bit more difficult to play due to the actual string spacing of 44 mm opposed to 42.5 mm of my other guitars. All to my surprise it didn't take more than 2 days to discover that this feels much more comfortable under my finders. I don't have really big hands but the extra space at the nut is really something whereas the scale length doesn't seem to have the same impact ... at least in my case which might be linked to almost 30 years of socialisation on a 54/667 guitar!?
Lessons learn are, don't care too much about numbers. Supposed a guitar really strikes you but feels a bit "strange" at the beginning, keep playing and carefully observe if and how this changes over time. Make breaks, play other guitars and return to find out if something changes. Supposed the "strange" feeling maintains, then it's up to you to decide if the overall performance of the guitar justifies some risk or not!